Frederick Southwick, MD » Division of Hospital Medicine » College of Medicine

Frederick S Southwick M.D.

PROF

Department: MD-HOSPITAL MEDICINE DIVISION

CV: View Curriculum Vitae:

Mailing Address:: 6362 NW 41ST AVE
GAINESVILLE FL 32606

Physical Address:: PO Box 100238
Division of Hospitalist Medicine
GAINESVILLE FL 32610

Accomplishments:

Advanced Leadership Initiative Fellow
2010 · Harvard Business School
Teaching Excellence Award
2001 · University of Florida
Award for distinguished research accomplishments
2001 · University of Florida Research Foundation
Elected Outstanding
2001 · Department of Medicine House Staff
Elected Member
2000 · Association of Professors of Medicine

Certifications:

Infectious Diseases
American Board of Internal Medicine
Internal Medicine
American Board of Internal Medicine

Specialties:

Hospital Medicine
Infectious Disease

Clinical Interests:

Anthrax
Atypical pneumonia
Community-acquired pneumonia in adults
Hospital-acquired pneumonia
Immunodeficiency disorders
Infectious diseases
Meningitis
Sepsis
Urinary tract infection – adults

Publications:

2022
Applying Lean principles to create a high throughput mass COVID-19 vaccination site.
BMJ open quality
2021
Neuraxial and peripheral misconnection events leading to wrong-route medication errors: a comprehensive literature review.
Regional anesthesia and pain medicine
2021
Increasing adherence to a standardized rounding procedure in two hospital in-patient units.
Journal of applied behavior analysis
2021
Improving the Definition of Coronavirus Disease 2019-Related Deaths.
The Journal of infectious diseases
2021
In response: neuraxial and peripheral misconnection events leading to wrong-route medication errors.
Regional anesthesia and pain medicine
2020
The Loss of Social Connectedness as a Major Contributor to Physician Burnout: Applying Organizational and Teamwork Principles for Prevention and Recovery.
JAMA psychiatry
2020
No human exists in isolation or as an island: The outcomes of a multidisciplinary, global, and context-specific COVID-19 consortium.
American journal of disaster medicine
2020
Health Care Provider Factors Associated with Patient-Reported Adverse Events and Harm.
Joint Commission journal on quality and patient safety
2020
Infectious diseases occurring in the context of substance use disorders: A concise review.
Journal of the Neurological Sciences
2019
Teaching novice clinicians how to reduce diagnostic waste and errors by applying the Toyota Production System.
Diagnosis (Berlin, Germany)
2018
Learning From Patients' Experiences Related To Diagnostic Errors Is Essential For Progress In Patient Safety.
Health affairs (Project Hope)
2018
The Loss of a Sense of Control as a Major Contributor to Physician Burnout: A Neuropsychiatric Pathway to Prevention and Recovery.
JAMA psychiatry
2016
The lazy leukocyte syndrome revisited.
Blood
2015
A patient-initiated voluntary online survey of adverse medical events: the perspective of 696 injured patients and families.
BMJ quality & safety
2014
Exserohilum rostratum: characterization of a cross-kingdom pathogen of plants and humans.
PloS one
2014
Applying athletic principles to medical rounds to improve teaching and patient care.
Academic medicine : journal of the Association of American Medical Colleges
2013
Myosin-X facilitates Shigella-induced membrane protrusions and cell-to-cell spread.
Cellular microbiology
2012
All'S Not Fair in Science and Publishing
Scientist
2012
Anthrax lethal and edema toxins fail to directly impair human platelet function.
The Journal of infectious diseases
2012
Bacillus anthracis' lethal toxin induces broad transcriptional responses in human peripheral monocytes.
BMC immunology
2012
Perspective: a business school view of medical interprofessional rounds: transforming rounding groups into rounding teams.
Academic medicine : journal of the Association of American Medical Colleges
2011
The potential influence of common viral infections diagnosed during hospitalization among critically ill patients in the United States.
PloS one
2010
Brucella, voles, and emerging pathogens.
The Journal of infectious diseases
2010
Commentary: IDSA guidelines for improving the teaching of preclinical medical microbiology and infectious diseases.
Academic medicine : journal of the Association of American Medical Colleges
2009
Commentary: "Who was caring for Mary?" revisited: a call for all academic physicians caring for patients to focus on systems and quality improvement.
Academic medicine : journal of the Association of American Medical Colleges
2009
Bacillus anthracis edema toxin impairs neutrophil actin-based motility.
Infection and immunity
2008
Methicillin-resistant Staphylococcus aureus infection in a college football team: risk factors outside the locker room and playing field.
Infection control and hospital epidemiology
2007
Theodore E. Woodward Award: spare me the PowerPoint and bring back the medical textbook.
Transactions of the American Clinical and Climatological Association
2007
Anthrax lethal toxin paralyzes actin-based motility by blocking Hsp27 phosphorylation.
The EMBO journal
2006
A CapG gain-of-function mutant reveals critical structural and functional determinants for actin filament severing.
The EMBO journal
2005
Anthrax lethal toxin paralyzes neutrophil actin-based motility.
The Journal of infectious diseases
2005
Gelsolin mediates calcium-dependent disassembly of Listeria actin tails.
Proceedings of the National Academy of Sciences of the United States of America
2005
Phosphoinositide 3-kinase is required for intracellular Listeria monocytogenes actin-based motility and filopod formation.
The Journal of biological chemistry
2003
Actin-based endosome and phagosome rocketing in macrophages: activation by the secretagogue antagonists lanthanum and zinc.
Cell motility and the cytoskeleton
2003
CapG(-/-) mice have specific host defense defects that render them more susceptible than CapG(+/+) mice to Listeria monocytogenes infection but not to Salmonella enterica serovar Typhimurium infection.
Infection and immunity
2003
Depolymerization of actin filaments by profilin. Effects of profilin on capping protein function.
The Journal of biological chemistry
2002
Importance of free actin filament barbed ends for Arp2/3 complex function in platelets and fibroblasts.
Proceedings of the National Academy of Sciences of the United States of America
2002
The Chediak-Higashi protein interacts with SNARE complex and signal transduction proteins.
Molecular medicine (Cambridge, Mass.)
2002
A direct-transfer polymerization model explains how the multiple profilin-binding sites in the actoclampin motor promote rapid actin-based motility.
Archives of biochemistry and biophysics
2002
Actin-based phagosome motility.
Cell motility and the cytoskeleton
2001
Comparisons of CapG and gelsolin-null macrophages: demonstration of a unique role for CapG in receptor-mediated ruffling, phagocytosis, and vesicle rocketing.
The Journal of cell biology
2001
N-WASP deficiency reveals distinct pathways for cell surface projections and microbial actin-based motility.
Nature cell biology
2001
Who was caring for Mary? 1993.
Obstetrics and gynecology
2000
Gelsolin and ADF/cofilin enhance the actin dynamics of motile cells.
Proceedings of the National Academy of Sciences of the United States of America
2000
Shigella actin-based motility in the presence of truncated vinculin.
Cell motility and the cytoskeleton
1999
Actin-based motility of the intracellular pathogen Listeria monocytogenes: assessing the inhibitory specificity of ABM-1 peptide analogues.
Molecular cell biology research communications : MCBRC
1999
Energetics of nucleotide hydrolysis in polymer assembly/disassembly: the cases of actin and tubulin.
Methods in enzymology
1999
Profilin promotes barbed-end actin filament assembly without lowering the critical concentration.
The Journal of biological chemistry
1998
Gelsolin, a protein that caps the barbed ends and severs actin filaments, enhances the actin-based motility of Listeria monocytogenes in host cells.
Infection and immunity
1998
Listeria and Shigella actin-based motility in host cells.
Transactions of the American Clinical and Climatological Association
1998
Vaccinia locomotion in host cells: evidence for the universal involvement of actin-based motility sequences ABM-1 and ABM-2.
Proceedings of the National Academy of Sciences of the United States of America
1997
ABM-1 and ABM-2 homology sequences: consensus docking sites for actin-based motility defined by oligoproline regions in Listeria ActA surface protein and human VASP.
Biochemical and biophysical research communications
1997
Profilin interacts with the Gly-Pro-Pro-Pro-Pro-Pro sequences of vasodilator-stimulated phosphoprotein (VASP): implications for actin-based Listeria motility.
Biochemistry
1997
Vinculin proteolysis unmasks an ActA homolog for actin-based Shigella motility.
The Journal of cell biology
1996
Intracellular pathogenesis of listeriosis.
The New England journal of medicine
1996
Purification and properties of a Ca(2+)-independent barbed-end actin filament capping protein, CapZ, from human polymorphonuclear leukocytes.
Biochemistry
1996
Recognition of two classes of oligoproline sequences in profilin-mediated acceleration of actin-based Shigella motility.
The Journal of cell biology
1995
Gain-of-function mutations conferring actin-severing activity to human macrophage cap G.
The Journal of biological chemistry
1995
Inhibition of Listeria locomotion by mosquito oostatic factor, a natural oligoproline peptide uncoupler of profilin action.
Infection and immunity
1995
Listeria monocytogenes intracellular migration: inhibition by profilin, vitamin D-binding protein and DNase I.
Cell motility and the cytoskeleton
1995
Septic thrombophlebitis of major dural venous sinuses.
Current clinical topics in infectious diseases
1994
The human actin-regulatory protein cap G: gene structure and chromosome location.
Genomics
1994
Dynamic remodeling of the actin cytoskeleton: lessons learned from Listeria locomotion.
BioEssays : news and reviews in molecular, cellular and developmental biology
1994
Calcium regulation of actin filament capping and monomer binding by macrophage capping protein.
The Journal of biological chemistry
1994
Arrest of Listeria movement in host cells by a bacterial ActA analogue: implications for actin-based motility.
Proceedings of the National Academy of Sciences of the United States of America
1993
Acute bacterial meningitis in adults. A review of 493 episodes.
The New England journal of medicine
1993
Diminished actin polymerization by neutrophils from newborn infants.
Pediatric research
1993
Who was caring for Mary?
Annals of internal medicine
1992
Host cell actin assembly is necessary and likely to provide the propulsive force for intracellular movement of Listeria monocytogenes.
Infection and immunity
1992
Molecular cloning of human macrophage capping protein cDNA. A unique member of the gelsolin/villin family expressed primarily in macrophages.
The Journal of biological chemistry
1991
Binding of IgG containing immune complexes to human neutrophil Fc gamma RII and Fc gamma RIII induces actin polymerization by a pertussis toxin-insensitive transduction pathway.
Journal of immunology (Baltimore, Md. : 1950)
1991
Stimulation of human polymorphonuclear leukocyte phosphatidylinositol-4-phosphate kinase by concanavalin A and formyl-methionyl-leucyl-phenylalanine is calcium-independent. Correlation with maintenance of actin assembly.
Journal of immunology (Baltimore, Md. : 1950)
1990
Septic cortical thrombophlebitis.
The Journal of infectious diseases
1990
The actin released from profilin–actin complexes is insufficient to account for the increase in F-actin in chemoattractant-stimulated polymorphonuclear leukocytes.
The Journal of cell biology
1990
Kinetics of the interaction of a 41-kilodalton macrophage capping protein with actin: promotion of nucleation during prolongation of the lag period.
Biochemistry
1990
Listeria monocytogenes moves rapidly through the host-cell cytoplasm by inducing directional actin assembly.
Proceedings of the National Academy of Sciences of the United States of America
1989
Polymorphonuclear leukocyte adherence induces actin polymerization by a transduction pathway which differs from that used by chemoattractants.
The Journal of cell biology
1989
The relationship between CR3 deficiency and neutrophil actin assembly.
Blood
1988
Contractile proteins in leukocytes.
Methods in enzymology
1988
Neutrophil actin dysfunction is a genetic disorder associated with partial impairment of neutrophil actin assembly in three family members.
The Journal of clinical investigation
1988
Recurrent cystitis and bladder mass in two adults with chronic granulomatous disease.
Annals of internal medicine
1987
Platelet-activating factor both stimulates and "primes" human polymorphonuclear leukocyte actin filament assembly.
Blood
1986
Rabbit alveolar macrophages contain a Ca2+-sensitive, 41,000-dalton protein which reversibly blocks the "barbed" ends of actin filaments but does not sever them.
The Journal of biological chemistry
1986
Septic thrombosis of the dural venous sinuses.
Medicine
1985
Effects of macrophage profilin on actin in the presence and absence of acumentin and gelsolin.
The Journal of biological chemistry
1985
Nonmuscle actin-binding proteins.
Annual review of cell biology
1984
The motor of leukocytes.
Federation proceedings
1984
Sphenoid sinusitis.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
1984
An analogue of the erythroid membrane skeletal protein 4.1 in nonerythroid cells.
The Journal of cell biology
1983
Contractile proteins in leukocyte function.
Seminars in hematology
1983
Sphenoid sinusitis. A review of 30 cases.
The New England journal of medicine
1982
Acumentin, a protein in macrophages which caps the "pointed" end of action filaments.
Nature
1982
Acumentin, an actin-modulating protein of rabbit pulmonary macrophages.
Biochemistry
1981
A variant of chronic granulomatous disease: deficient oxidative metabolism due to a low-affinity NADPH oxidase.
The New England journal of medicine
1981
Isolation of an inhibitor of actin polymerization from human polymorphonuclear leukocytes.
The Journal of biological chemistry
1980
An inherited abnormality of neutrophil adhesion. Its genetic transmission and its association with a missing protein.
The New England journal of medicine
1980
Hemophilus influenzae in hospitalized adults: current perspectives.
The American journal of medicine
1979
Defective leukocyte metabolism.
The New England journal of medicine
1977
Multifactorial index of cardiac risk in noncardiac surgical procedures.
The New England journal of medicine

Education:

1980
Fellowship – Infectious Disease
Massachusetts General Hospital
1976
Residency – Internal Medicine
Massachusetts General Hospital
1975
Residency – Internal Medicine
Boston City Hospital
1974
Internship – Internal Medicine
Boston City Hospital
1973
Medical Degree
Columbia University

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